Assay Detail
Functional
CHEMBL687598
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to antagonize the 8-OH-DPAT-induced contractions of a strip of guinea pig ileum tissue
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and in vitro and in vivo functional studies of ortho-substituted phenylpiperazine and N-substituted 4-N-(o-methoxyphenyl)aminopiperidine analogues of WAY100635.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 8.30 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31354 | WAY-100,635 | — | 1 | 8.70 |
| CHEMBL335504 | — | — | 1 | 8.60 |
| CHEMBL137298 | — | — | 1 | 8.50 |
| CHEMBL342198 | — | — | 1 | 8.30 |
| CHEMBL423361 | — | — | 1 | 8.00 |
| CHEMBL139205 | — | — | 1 | 7.70 |
| CHEMBL136548 | — | — | 1 | - |
| CHEMBL136121 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31354 | WAY-100,635 | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL335504 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL137298 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL342198 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL423361 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL139205 | — | Kd | = | 19.95 | nM | 7.70 |
| CHEMBL136548 | — | Kd | > | 100.0 | nM | - |
| CHEMBL136121 | — | Kd | > | 100.0 | nM | - |