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Assay Detail

CHEMBL687659

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Activity was evaluated by measuring the inhibition of isolated hog H+/K+ ATPase
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 7 — Homologous single protein target
Curated By Intermediate

Target

Potassium-transporting ATPase (CHEMBL2095228)
Type PROTEIN COMPLEX
Organism Sus scrofa

Publication

Studies on (H(+)-K+)-ATPase inhibitors of gastric acid secretion. Prodrugs of 2-[(2-pyridinylmethyl)sulfinyl]benzimidazole proton-pump inhibitors.
Sih JC, Im WB, Robert A, Graber DR, Blakeman DP.
J Med Chem (1991) 34 : 1049 -1062
PubMed 1848293 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 4.76 5.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL10021 1 5.30
CHEMBL275917 1 5.10
CHEMBL9964 1 5.00
CHEMBL9972 1 5.00
CHEMBL264214 DISUPRAZOLE 2.0 1 4.70
CHEMBL10184 1 4.70
CHEMBL10149 1 4.70
CHEMBL276824 1 4.70
CHEMBL9913 1 4.70
CHEMBL275283 1 4.70
CHEMBL9842 1 4.52
CHEMBL9828 1 4.52
CHEMBL1503 OMEPRAZOLE 4.0 1 4.30
CHEMBL9829 1 -
CHEMBL9862 1 -
CHEMBL268465 1 -
CHEMBL10209 1 -
CHEMBL9857 1 -
CHEMBL269173 1 -
CHEMBL267811 2 -
CHEMBL276437 1 -
CHEMBL10204 1 -
CHEMBL10087 1 -
CHEMBL10485 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL10021 IC50 = 5000.0 nM 5.30
CHEMBL275917 IC50 = 8000.0 nM 5.10
CHEMBL9964 IC50 = 10000.0 nM 5.00
CHEMBL9972 IC50 = 10000.0 nM 5.00
CHEMBL264214 DISUPRAZOLE IC50 = 20000.0 nM 4.70
CHEMBL10184 IC50 = 20000.0 nM 4.70
CHEMBL10149 IC50 = 20000.0 nM 4.70
CHEMBL276824 IC50 = 20000.0 nM 4.70
CHEMBL9913 IC50 = 20000.0 nM 4.70
CHEMBL275283 IC50 = 20000.0 nM 4.70
CHEMBL9842 IC50 = 30000.0 nM 4.52
CHEMBL9828 IC50 = 30000.0 nM 4.52
CHEMBL1503 OMEPRAZOLE IC50 = 50000.0 nM 4.30
CHEMBL9829 IC50 > 1000000.0 nM -
CHEMBL9862 IC50 = 1000000.0 nM -
CHEMBL268465 IC50 = 200000.0 nM -
CHEMBL267811 IC50 = 10000000000.0 nM -
CHEMBL10209 IC50 = 500000.0 nM -
CHEMBL9857 IC50 = 1500000.0 nM -
CHEMBL269173 IC50 = 1000000.0 nM -
CHEMBL267811 IC50 = 10000000000.0 nM -
CHEMBL276437 IC50 = 400000.0 nM -
CHEMBL10204 IC50 = 400000.0 nM -
CHEMBL10087 IC50 = 1000000.0 nM -
CHEMBL10485 IC50 = 1500000.0 nM -