Compound Detail
CHEMBL264214
DISUPRAZOLE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL264214 |
| Name | DISUPRAZOLE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | YWQUFKJVMWHDSN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
2
Known Names
Molecular Properties
331.5
MW (Da)
3.69
ALogP
4
HBA
1
HBD
64.6
PSA (Ų)
0.57
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 1 meas. best 4.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium-transporting ATPase CHEMBL2095228 | IC50 | 4.7 | 4.7 | 20000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium-transporting ATPase | IC50 | = | 20000.0 | nM | 4.7 | Activity was evaluated by measuring the inhibition of isolated hog H+/K+ ATPase | 1848293 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1848293 | 10.1021/jm00107a026 | Potassium-transporting ATPase | 2 |
| 1848293 | 10.1021/jm00107a026 | Oryctolagus cuniculus | 1 |
| 1848293 | 10.1021/jm00107a026 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine