Assay Detail
Functional
CHEMBL687938
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect in isolated tissues of guinea pig ileum(GPI).
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 9.09 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121211 | — | — | 2 | 10.10 |
| CHEMBL333410 | — | — | 1 | 9.38 |
| CHEMBL121403 | — | — | 1 | 9.09 |
| CHEMBL338510 | — | — | 1 | 9.04 |
| CHEMBL121494 | — | — | 1 | 8.36 |
| CHEMBL121060 | — | — | 1 | - |
| CHEMBL435380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121211 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL333410 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL121403 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL338510 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL121211 | — | IC50 | = | 2.58 | nM | 8.59 |
| CHEMBL121494 | — | IC50 | = | 4.33 | nM | 8.36 |
| CHEMBL121060 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL435380 | — | IC50 | > | 1000.0 | nM | - |