Assay Detail
Functional
CHEMBL687941
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Mu opioid receptor agonist activity as inhibition of electrically stimulated mysenteric plexus in guinea pig ileum
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of a metazocine-containing enkephalinamide. Evidence for nonidentical roles of the tyramine moiety in opiates and opioid peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.31 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL595972 | — | — | 1 | 7.76 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.24 |
| CHEMBL257661 | METAZOCINE | 2.0 | 1 | 7.03 |
| CHEMBL441776 | — | — | 2 | 6.29 |
| CHEMBL285083 | — | — | 1 | 5.55 |
| CHEMBL284060 | — | — | 1 | 5.21 |
| CHEMBL2372185 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL595972 | — | IC50 | = | 17.4 | nM | 7.76 |
| CHEMBL70 | MORPHINE | IC50 | = | 57.3 | nM | 7.24 |
| CHEMBL257661 | METAZOCINE | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL441776 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL441776 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL285083 | — | IC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL284060 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL2372185 | — | IC50 | = | 7970.0 | nM | 5.10 |