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Assay Detail

CHEMBL687942

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition electrically stimulated guinea pig ileum segment contraction.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Tissue Ileum
Confidence 1 — Organism
Curated By Expert

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.
Somers F, Ouedraogo R, Antoine MH, de Tullio P, Becker B, Fontaine J, Damas J, Dupont L, Rigo B, Delarge J, Lebrun P, Pirotte B.
J Med Chem (2001) 44 : 2575 -2585
PubMed 11472211 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 4.66 5.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL420420 1 5.09
CHEMBL420421 1 5.06
CHEMBL1159 PINACIDIL ANHYDROUS 4.0 1 5.04
CHEMBL2114213 1 4.88
CHEMBL86644 1 4.88
CHEMBL87689 1 4.82
CHEMBL312833 1 4.70
CHEMBL87681 1 4.63
CHEMBL87944 1 4.62
CHEMBL315543 1 4.58
CHEMBL87720 1 4.52
CHEMBL87565 1 4.36
CHEMBL83630 1 4.35
CHEMBL86591 1 4.23
CHEMBL85853 1 4.13
CHEMBL32111 1 -
CHEMBL181 DIAZOXIDE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL420420 IC50 = 8200.0 nM 5.09
CHEMBL420421 IC50 = 8700.0 nM 5.06
CHEMBL1159 PINACIDIL ANHYDROUS IC50 = 9200.0 nM 5.04
CHEMBL2114213 IC50 = 13200.0 nM 4.88
CHEMBL86644 IC50 = 13300.0 nM 4.88
CHEMBL87689 IC50 = 15100.0 nM 4.82
CHEMBL312833 IC50 = 20200.0 nM 4.70
CHEMBL87681 IC50 = 23600.0 nM 4.63
CHEMBL87944 IC50 = 23900.0 nM 4.62
CHEMBL315543 IC50 = 26000.0 nM 4.58
CHEMBL87720 IC50 = 30400.0 nM 4.52
CHEMBL87565 IC50 = 44100.0 nM 4.36
CHEMBL83630 IC50 = 44700.0 nM 4.35
CHEMBL86591 IC50 = 59200.0 nM 4.23
CHEMBL85853 IC50 = 74100.0 nM 4.13
CHEMBL32111 IC50 > 300000.0 nM -
CHEMBL181 DIAZOXIDE IC50 > 300000.0 nM -