Assay Detail
Functional
CHEMBL687947
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Tested for concentration required to inhibit H1 histamine -induced guinea pig ileum contraction
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
[(3-Pyridylalkyl)piperidylidene]benzocycloheptapyridine derivatives as dual antagonists of PAF and histamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.85 | 7.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329370 | — | — | 1 | 7.47 |
| CHEMBL91565 | — | — | 1 | 7.46 |
| CHEMBL423316 | — | — | 1 | 7.03 |
| CHEMBL10971 | SCH-37370 | — | 1 | 7.00 |
| CHEMBL998 | LORATADINE | 4.0 | 1 | 6.54 |
| CHEMBL329826 | — | — | 1 | 6.46 |
| CHEMBL420809 | — | — | 1 | 6.42 |
| CHEMBL90398 | — | — | 1 | 6.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329370 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL91565 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL423316 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL10971 | SCH-37370 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL998 | LORATADINE | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL329826 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL420809 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL90398 | — | IC50 | = | 390.0 | nM | 6.41 |