Assay Detail
Functional
CHEMBL687954
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The inhibitory concentration activity was measured on guinea pig ileum (GPI)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Conformationally constrained deltorphin analogs with 2-aminotetralin-2-carboxylic acid in position 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.94 | 5.67 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL433978 | — | — | 1 | 5.67 |
| CHEMBL175116 | — | — | 1 | 5.38 |
| CHEMBL177647 | — | — | 1 | 5.18 |
| CHEMBL369499 | — | — | 1 | 4.71 |
| CHEMBL426776 | — | — | 1 | 4.50 |
| CHEMBL433720 | — | — | 1 | 4.17 |
| CHEMBL296603 | DELTORPHINE II | — | 1 | - |
| CHEMBL281140 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL433978 | — | IC50 | = | 2162.0 | nM | 5.67 |
| CHEMBL175116 | — | IC50 | = | 4210.0 | nM | 5.38 |
| CHEMBL177647 | — | IC50 | = | 6618.0 | nM | 5.18 |
| CHEMBL369499 | — | IC50 | = | 19570.0 | nM | 4.71 |
| CHEMBL426776 | — | IC50 | = | 31270.0 | nM | 4.50 |
| CHEMBL433720 | — | IC50 | = | 67250.0 | nM | 4.17 |
| CHEMBL296603 | DELTORPHINE II | IC50 | > | 1500.0 | nM | - |
| CHEMBL281140 | — | IC50 | > | 3000.0 | nM | - |