Assay Detail
Functional
CHEMBL687955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The opioid activity by guinea pig ileum assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.74 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL384584 | — | — | 1 | 9.66 |
| CHEMBL442323 | — | — | 1 | 8.67 |
| CHEMBL406338 | — | — | 1 | 7.74 |
| CHEMBL267215 | — | — | 1 | 6.64 |
| CHEMBL268818 | — | — | 1 | 6.00 |
| CHEMBL406893 | — | — | 1 | - |
| CHEMBL266782 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL384584 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL442323 | — | IC50 | = | 2.16 | nM | 8.67 |
| CHEMBL406338 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL267215 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL268818 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL406893 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL266782 | — | IC50 | > | 3000.0 | nM | - |