Assay Detail
Functional
CHEMBL688167
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Opioid antagonist activity in guinea pig ileum assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and opioid activity of [D-Pro10]dynorphin A-(1-11) analogues with N-terminal alkyl substitution.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.52 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70 | MORPHINE | 4.0 | 1 | 8.20 |
| CHEMBL406338 | — | — | 1 | 7.60 |
| CHEMBL406893 | — | — | 1 | 7.30 |
| CHEMBL442323 | — | — | 1 | 7.30 |
| CHEMBL384584 | — | — | 1 | 7.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70 | MORPHINE | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL406338 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL406893 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL442323 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL384584 | — | Kd | = | 63.1 | nM | 7.20 |