Assay Detail
Functional
CHEMBL688168
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for the pA2 value that was estimated using 2-methyl-5-HT in five to seven different tissues in guinea pig ileum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 2-piperazinylbenzothiazole and 2-piperazinylbenzoxazole derivatives with 5-HT3 antagonist and 5-HT4 agonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.18 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1729 | CISAPRIDE | 4.0 | 1 | 9.00 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 6.90 |
| CHEMBL24909 | — | — | 1 | 6.50 |
| CHEMBL282234 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1729 | CISAPRIDE | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL46 | ONDANSETRON | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL24909 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL282234 | — | Kd | = | 501.19 | nM | 6.30 |