Assay Detail
Functional
CHEMBL688360
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Tested for the cytotoxicity to inhibit replication assay against the human colon tumor cell line HCT116
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Inhibition of topoisomerase II catalytic activity by pyridoacridine alkaloids from a Cystodytes sp. ascidian: a mechanism for the apparent intercalator-induced inhibition of topoisomerase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.23 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339820 | — | — | 1 | 5.80 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.60 |
| CHEMBL127811 | EILATIN | — | 1 | 5.28 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 5.20 |
| CHEMBL127872 | KUANONIAMINE D | — | 1 | 5.11 |
| CHEMBL127873 | SHERMILAMINE B | — | 1 | 4.86 |
| CHEMBL127939 | — | — | 1 | 4.79 |
| CHEMBL124579 | DIPLAMINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339820 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL127811 | EILATIN | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL43 | AMSACRINE | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL127872 | KUANONIAMINE D | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL127873 | SHERMILAMINE B | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL127939 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL124579 | DIPLAMINE | IC50 | < | 1400.0 | nM | - |