Compound Detail
CHEMBL127811
EILATIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL127811 |
| Name | EILATIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XLONQTAYDCFVPP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
356.4
MW (Da)
5.62
ALogP
4
HBA
0
HBD
51.6
PSA (Ų)
0.26
QED
1
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.88
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei brucei CHEMBL612851 | IC50 | 5.88 | 5.88 | 1330.0 | 1 |
| HCT-116 CHEMBL394 | IC50 | 5.28 | 5.28 | 5300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei brucei | IC50 | = | 1330.0 | nM | 5.88 | Antitrypanosomal activity against Trypanosoma brucei brucei | 22204643 |
| HCT-116 | IC50 | = | 5300.0 | nM | 5.28 | Tested for the cytotoxicity to inhibit replication assay against the human colon... | 7525959 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 7525959 | 10.1021/jm00048a017 | HCT-116 | 1 |
| 7525959 | 10.1021/jm00048a017 | ADMET | 1 |
| 7525959 | 10.1021/jm00048a017 | NON-PROTEIN TARGET | 1 |
| 7525959 | 10.1021/jm00048a017 | DNA topoisomerase II | 1 |
| 7525959 | 10.1021/jm00048a017 | Unchecked | 1 |
| 22204643 | 10.1021/np200687v | Trypanosoma brucei brucei | 1 |
Data from ChEMBL 36 via Core Engine