Assay Detail
Functional
CHEMBL689043
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Binding affinity against smooth muscle tissue of Guinea pig ileum
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Smooth muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis using a Fmoc-based strategy and biological activities of some reduced peptide bond pseudopeptide analogues of dynorphin A1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.94 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL216640 | — | — | 1 | 8.96 |
| CHEMBL2370495 | — | — | 1 | 8.68 |
| CHEMBL2370494 | — | — | 1 | 8.55 |
| CHEMBL2370496 | — | — | 1 | 8.43 |
| CHEMBL2311023 | — | — | 1 | 7.78 |
| CHEMBL2311022 | — | — | 1 | 7.69 |
| CHEMBL2311025 | — | — | 1 | 7.68 |
| CHEMBL2370497 | — | — | 1 | 7.15 |
| CHEMBL2311024 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL216640 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2370495 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL2370494 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL2370496 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL2311023 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL2311022 | — | IC50 | = | 20.5 | nM | 7.69 |
| CHEMBL2311025 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2370497 | — | IC50 | = | 70.6 | nM | 7.15 |
| CHEMBL2311024 | — | IC50 | = | 308.0 | nM | 6.51 |