Assay Detail
Functional
CHEMBL689093
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for calcium channel agonistic activity, causing a 50% increase of the maximum contractile response on guinea pig left atrium.
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and calcium channel-modulating effects of alkyl (or cycloalkyl) 1,4-dihydro-2,6-dimethyl-3-nitro-4-pyridyl-5-pyridinecarboxylate racemates and enantiomers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.04 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1082832 | — | — | 1 | 6.11 |
| CHEMBL149385 | — | — | 1 | 5.76 |
| CHEMBL146521 | — | — | 1 | 5.56 |
| CHEMBL358981 | — | — | 1 | 5.55 |
| CHEMBL357902 | — | — | 1 | 5.48 |
| CHEMBL147490 | — | — | 2 | 5.43 |
| CHEMBL149133 | — | — | 1 | 5.37 |
| CHEMBL146700 | — | — | 1 | 5.31 |
| CHEMBL147237 | — | — | 1 | 5.19 |
| CHEMBL97381 | — | — | 1 | 5.09 |
| CHEMBL150160 | — | — | 1 | 5.07 |
| CHEMBL346450 | — | — | 1 | 5.05 |
| CHEMBL148686 | — | — | 1 | 5.04 |
| CHEMBL150066 | — | — | 1 | 5.01 |
| CHEMBL53390 | — | — | 1 | 5.01 |
| CHEMBL147513 | — | — | 1 | 4.84 |
| CHEMBL344744 | — | — | 1 | 4.70 |
| CHEMBL358611 | — | — | 1 | 4.64 |
| CHEMBL97047 | — | — | 1 | 4.54 |
| CHEMBL149036 | — | — | 1 | 4.42 |
| CHEMBL147289 | — | — | 1 | 4.31 |
| CHEMBL148478 | — | — | 1 | 4.31 |
| CHEMBL347738 | — | — | 1 | 4.16 |
| CHEMBL149773 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1082832 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL149385 | — | EC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL146521 | — | EC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL358981 | — | EC50 | = | 2820.0 | nM | 5.55 |
| CHEMBL357902 | — | EC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL147490 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL149133 | — | EC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL146700 | — | EC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL147237 | — | EC50 | = | 6460.0 | nM | 5.19 |
| CHEMBL97381 | — | EC50 | = | 8050.0 | nM | 5.09 |
| CHEMBL150160 | — | EC50 | = | 8510.0 | nM | 5.07 |
| CHEMBL147490 | — | EC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL346450 | — | EC50 | = | 8840.0 | nM | 5.05 |
| CHEMBL148686 | — | EC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL150066 | — | EC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL53390 | — | EC50 | = | 9670.0 | nM | 5.01 |
| CHEMBL147513 | — | EC50 | = | 14600.0 | nM | 4.84 |
| CHEMBL344744 | — | EC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL358611 | — | EC50 | = | 22800.0 | nM | 4.64 |
| CHEMBL97047 | — | EC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL149036 | — | EC50 | = | 37700.0 | nM | 4.42 |
| CHEMBL147289 | — | EC50 | = | 49400.0 | nM | 4.31 |
| CHEMBL148478 | — | EC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL347738 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL149773 | — | EC50 | = | 1810000.0 | nM | - |