Assay Detail
Functional
CHEMBL689148
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effective concentration against cytopathicity of HIV-1 strain (HTLV IIIB) in CEM cell line
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Deoxyribonucleoside 2'- or 3'-mixed disulfides: prodrugs to target ribonucleotide reductase and/or to inhibit HIV reverse transcription.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.77 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.40 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | 3.0 | 1 | 5.38 |
| CHEMBL450901 | — | — | 1 | 5.00 |
| CHEMBL62684 | — | — | 1 | 4.30 |
| CHEMBL444845 | — | — | 1 | - |
| CHEMBL465056 | — | — | 1 | - |
| CHEMBL87718 | — | — | 1 | - |
| CHEMBL85821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL483 | TENOFOVIR ANHYDROUS | EC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL450901 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL62684 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL444845 | — | EC50 | > | 65000.0 | nM | - |
| CHEMBL465056 | — | EC50 | > | 390000.0 | nM | - |
| CHEMBL87718 | — | EC50 | > | 65000.0 | nM | - |
| CHEMBL85821 | — | EC50 | > | 340000.0 | nM | - |