Assay Detail

CHEMBL689675

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Functional

Full pA2 value of compound at 0.3-100 nM concentration of mepyramine in guinea pig ileum

ChEMBL ↗

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Target

Cavia porcellus (CHEMBL369) ↗

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Primary target Cavia porcellus

CHEMBL369

Anchored from Assay target.

Protein identity Cavia porcellus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Tissue	Ileum
Confidence	1 — Organism
Curated By	Intermediate

Target

Cavia porcellus (CHEMBL369) ↗

Type	ORGANISM
Organism	Cavia porcellus

Publication

N(alpha)-imidazolylalkyl and pyridylalkyl derivatives of histaprodifen: synthesis and in vitro evaluation of highly potent histamine H(1)-receptor agonists.

Menghin S, Pertz HH, Kramer K, Seifert R, Schunack W, Elz S.
J Med Chem (2003) 46 : 5458 -5470
PubMed 14640554 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	1	9.07	9.07

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL90	HISTAMINE	4.0	1	9.07

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL90	HISTAMINE	Kd	=	0.8511	nM	9.07