Assay Detail
Functional
CHEMBL689683
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Leukotriene D4 induced contraction of guinea-pig trachea was determined
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
The discovery of a new structural class of potent orally active leukotriene D4 antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 8.87 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275357 | — | — | 1 | 9.40 |
| CHEMBL15306 | — | — | 1 | 9.10 |
| CHEMBL277533 | — | — | 1 | 8.80 |
| CHEMBL15177 | MK-571 | — | 1 | 8.80 |
| CHEMBL15161 | L-695499 | — | 1 | 8.80 |
| CHEMBL274913 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275357 | — | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL15306 | — | Kd | = | 0.7943 | nM | 9.10 |
| CHEMBL277533 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL15177 | MK-571 | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL15161 | L-695499 | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL274913 | — | Kd | = | 5.012 | nM | 8.30 |