Assay Detail
Functional
CHEMBL689686
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Inhibition of histamine-inducedcontraction of the isolated guinea-pig ileum
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Optical isomers of the H1 antihistamine terfenadine: synthesis and activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 7.66 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432527 | — | — | 1 | 7.72 |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 7.65 |
| CHEMBL303454 | R-TERFENADINE | — | 1 | 7.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432527 | — | Kd | = | 19.05 | nM | 7.72 |
| CHEMBL17157 | TERFENADINE | Kd | = | 22.39 | nM | 7.65 |
| CHEMBL303454 | R-TERFENADINE | Kd | = | 24.55 | nM | 7.61 |