Assay Detail
Functional
CHEMBL689689
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In vitro activity to inhibit leukotriene D4 induced contraction of guinea pig trachea
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
3,4-Dihydro-2H-1-benzopyran-2-carboxylic acids and related compounds as leukotriene antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 6.23 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22016 | ABLUKAST | 2.0 | 1 | 6.60 |
| CHEMBL54955 | — | — | 1 | 6.20 |
| CHEMBL55164 | — | — | 1 | 6.10 |
| CHEMBL267475 | FPL-55712 | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22016 | ABLUKAST | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL54955 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL55164 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL267475 | FPL-55712 | Kd | = | 1000.0 | nM | 6.00 |