Assay Detail
Functional
CHEMBL689690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative log concentration effecting 50% blockade of isoproterenol-induced rate responses in vitro in guinea pig right atria.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Ultra-short-acting beta-adrenergic receptor blocking agents. 3. Ethylenediamine derivatives of (aryloxy)propanolamines having esters on the aryl function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 26 | 8.14 | 9.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13110 | — | — | 1 | 9.90 |
| CHEMBL13111 | — | — | 1 | 9.70 |
| CHEMBL13228 | — | — | 1 | 9.40 |
| CHEMBL12984 | — | — | 1 | 8.90 |
| CHEMBL13365 | — | — | 1 | 8.80 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 8.70 |
| CHEMBL6920 | — | — | 1 | 8.60 |
| CHEMBL12748 | — | — | 1 | 8.60 |
| CHEMBL268715 | — | — | 1 | 8.60 |
| CHEMBL13666 | — | — | 1 | 8.50 |
| CHEMBL13284 | — | — | 1 | 8.30 |
| CHEMBL12657 | — | — | 1 | 8.30 |
| CHEMBL13358 | — | — | 1 | 8.30 |
| CHEMBL273930 | — | — | 1 | 8.30 |
| CHEMBL13299 | — | — | 1 | 8.10 |
| CHEMBL13384 | — | — | 1 | 8.10 |
| CHEMBL12903 | — | — | 1 | 7.60 |
| CHEMBL276385 | — | — | 1 | 7.50 |
| CHEMBL12873 | — | — | 1 | 7.50 |
| CHEMBL13131 | — | — | 1 | 7.30 |
| CHEMBL13504 | — | — | 1 | 6.80 |
| CHEMBL13098 | — | — | 1 | 6.80 |
| CHEMBL13197 | — | — | 1 | 6.50 |
| CHEMBL13198 | — | — | 1 | 6.20 |
| CHEMBL13335 | — | — | 1 | - |
| CHEMBL12902 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13110 | — | Kd | = | 0.1259 | nM | 9.90 |
| CHEMBL13111 | — | Kd | = | 0.1995 | nM | 9.70 |
| CHEMBL13228 | — | Kd | = | 0.3981 | nM | 9.40 |
| CHEMBL12984 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL13365 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL27 | PROPRANOLOL | Kd | = | 1.995 | nM | 8.70 |
| CHEMBL6920 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL12748 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL268715 | — | Kd | = | 2.512 | nM | 8.60 |
| CHEMBL13666 | — | Kd | = | 3.162 | nM | 8.50 |
| CHEMBL13284 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL12657 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL13358 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL273930 | — | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL13299 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL13384 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL12903 | — | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL276385 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL12873 | — | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL13131 | — | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL13504 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL13098 | — | Kd | = | 158.49 | nM | 6.80 |
| CHEMBL13197 | — | Kd | = | 316.23 | nM | 6.50 |
| CHEMBL13198 | — | Kd | = | 630.96 | nM | 6.20 |
| CHEMBL13335 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL12902 | — | Kd | > | 1000.0 | nM | - |