Assay Detail
Functional
CHEMBL689695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of contractions in the electrically stimulated guinea pig ileum.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and pharmacological activity of partially modified retro-inverso dermorphin tetrapeptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.82 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164983 | — | — | 1 | 9.51 |
| CHEMBL351419 | — | — | 1 | 9.30 |
| CHEMBL166038 | — | — | 1 | 9.23 |
| CHEMBL278789 | DERMORPHIN | — | 1 | 8.85 |
| CHEMBL165745 | — | — | 1 | 8.69 |
| CHEMBL166081 | — | — | 1 | 8.69 |
| CHEMBL351202 | — | — | 1 | 8.67 |
| CHEMBL348764 | — | — | 1 | 8.53 |
| CHEMBL165319 | — | — | 1 | 8.35 |
| CHEMBL165551 | — | — | 1 | 7.74 |
| CHEMBL165654 | — | — | 1 | 7.72 |
| CHEMBL351087 | — | — | 1 | 7.60 |
| CHEMBL350348 | — | — | 1 | 7.51 |
| CHEMBL351861 | — | — | 1 | 7.41 |
| CHEMBL349816 | — | — | 1 | 7.34 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 7.23 |
| CHEMBL164786 | — | — | 1 | 6.97 |
| CHEMBL424181 | — | — | 1 | 6.72 |
| CHEMBL350979 | — | — | 1 | 6.62 |
| CHEMBL348845 | — | — | 1 | 6.50 |
| CHEMBL166084 | — | — | 1 | 6.48 |
| CHEMBL434680 | — | — | 1 | 6.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164983 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL351419 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL166038 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL278789 | DERMORPHIN | IC50 | = | 1.41 | nM | 8.85 |
| CHEMBL165745 | — | IC50 | = | 2.05 | nM | 8.69 |
| CHEMBL166081 | — | IC50 | = | 2.05 | nM | 8.69 |
| CHEMBL351202 | — | IC50 | = | 2.12 | nM | 8.67 |
| CHEMBL348764 | — | IC50 | = | 2.97 | nM | 8.53 |
| CHEMBL165319 | — | IC50 | = | 4.45 | nM | 8.35 |
| CHEMBL165551 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL165654 | — | IC50 | = | 19.2 | nM | 7.72 |
| CHEMBL351087 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL350348 | — | IC50 | = | 31.2 | nM | 7.51 |
| CHEMBL351861 | — | IC50 | = | 39.2 | nM | 7.41 |
| CHEMBL349816 | — | IC50 | = | 45.2 | nM | 7.34 |
| CHEMBL70 | MORPHINE | IC50 | = | 58.6 | nM | 7.23 |
| CHEMBL164786 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL424181 | — | IC50 | = | 191.2 | nM | 6.72 |
| CHEMBL350979 | — | IC50 | = | 242.5 | nM | 6.62 |
| CHEMBL348845 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL166084 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL434680 | — | IC50 | = | 380.1 | nM | 6.42 |