Assay Detail
Functional
CHEMBL689696
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In vitro inhibitory concentration against electrically induced twitches in guinea pig ileum
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Development of potent bifunctional endomorphin-2 analogues with mixed mu-/delta-opioid agonist and delta-opioid antagonist properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.25 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL331325 | — | — | 1 | 10.15 |
| CHEMBL334147 | — | — | 1 | 9.59 |
| CHEMBL339417 | — | — | 1 | 9.31 |
| CHEMBL433643 | — | — | 1 | 9.03 |
| CHEMBL120758 | — | — | 1 | 8.63 |
| CHEMBL332196 | — | — | 1 | 8.30 |
| CHEMBL333357 | ENDOMORPHIN 2 | — | 1 | 8.24 |
| CHEMBL331255 | — | — | 1 | 8.21 |
| CHEMBL327036 | — | — | 1 | 8.04 |
| CHEMBL409907 | — | — | 1 | 7.93 |
| CHEMBL118942 | — | — | 1 | 7.82 |
| CHEMBL419591 | — | — | 1 | 7.66 |
| CHEMBL120091 | — | — | 1 | 7.42 |
| CHEMBL332371 | — | — | 1 | 7.14 |
| CHEMBL333350 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL331325 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL334147 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL339417 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL433643 | — | IC50 | = | 0.94 | nM | 9.03 |
| CHEMBL120758 | — | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL332196 | — | IC50 | = | 5.03 | nM | 8.30 |
| CHEMBL333357 | ENDOMORPHIN 2 | IC50 | = | 5.79 | nM | 8.24 |
| CHEMBL331255 | — | IC50 | = | 6.21 | nM | 8.21 |
| CHEMBL327036 | — | IC50 | = | 9.14 | nM | 8.04 |
| CHEMBL409907 | — | IC50 | = | 11.8 | nM | 7.93 |
| CHEMBL118942 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL419591 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL120091 | — | IC50 | = | 37.7 | nM | 7.42 |
| CHEMBL332371 | — | IC50 | = | 72.8 | nM | 7.14 |
| CHEMBL333350 | — | IC50 | = | 445.0 | nM | 6.35 |