Assay Detail
Functional
CHEMBL689934
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Antiviral activity against herpes simplex virus using ELISA
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human alphaherpesvirus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and thiosangivamycin: the effect of certain 4- and 4,6-substituents on the antiviral activity of pyrrolo[2,3-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 4.48 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.52 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.47 |
| CHEMBL119691 | — | — | 1 | 4.90 |
| CHEMBL324910 | — | — | 1 | 4.22 |
| CHEMBL117384 | — | — | 1 | 4.17 |
| CHEMBL117969 | — | — | 1 | 4.07 |
| CHEMBL116338 | — | — | 1 | 4.00 |
| CHEMBL115708 | — | — | 1 | 4.00 |
| CHEMBL332925 | — | — | 1 | 4.00 |
| CHEMBL334041 | — | — | 1 | - |
| CHEMBL446672 | — | — | 1 | - |
| CHEMBL115689 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182 | GANCICLOVIR | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL184 | ACYCLOVIR | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL119691 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL324910 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL117384 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL117969 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL116338 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL115708 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL332925 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL334041 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL446672 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL115689 | — | IC50 | > | 100000.0 | nM | - |