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Assay Detail

CHEMBL690849

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration for hydrolysis of phosphoinositide in guinea pig pancreatic Acini
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Cavia porcellus
Confidence 1 — Organism
Curated By Expert

Target

Cavia porcellus (CHEMBL369)
Type ORGANISM
Organism Cavia porcellus

Publication

Boc-CCK-4 derivatives containing side-chain ureas as potent and selective CCK-a receptor agonists.
Shiosaki K, Lin CW, Kopecka H, Tufano MD, Bianchi BR, Miller TR, Witte DG, Nadzan AM.
J Med Chem (1991) 34 : 2837 -2842
PubMed 1716682 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 16 7.50 8.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1121 SINCALIDE 4.0 1 8.92
CHEMBL156559 1 8.47
CHEMBL319340 1 8.34
CHEMBL3142693 1 8.21
CHEMBL100609 1 8.08
CHEMBL320868 1 7.92
CHEMBL3142705 1 7.85
CHEMBL3142903 1 7.68
CHEMBL98468 1 7.29
CHEMBL319814 1 7.28
CHEMBL3142682 1 7.26
CHEMBL3142683 1 6.85
CHEMBL262767 1 6.85
CHEMBL3142703 1 6.51
CHEMBL3142689 1 6.48
CHEMBL328422 1 6.04

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1121 SINCALIDE EC50 = 1.2 nM 8.92
CHEMBL156559 EC50 = 3.4 nM 8.47
CHEMBL319340 EC50 = 4.6 nM 8.34
CHEMBL3142693 EC50 = 6.2 nM 8.21
CHEMBL100609 EC50 = 8.4 nM 8.08
CHEMBL320868 EC50 = 12.0 nM 7.92
CHEMBL3142705 EC50 = 14.0 nM 7.85
CHEMBL3142903 EC50 = 21.0 nM 7.68
CHEMBL98468 EC50 = 51.0 nM 7.29
CHEMBL319814 EC50 = 53.0 nM 7.28
CHEMBL3142682 EC50 = 55.0 nM 7.26
CHEMBL3142683 EC50 = 140.0 nM 6.85
CHEMBL262767 EC50 = 140.0 nM 6.85
CHEMBL3142703 EC50 = 310.0 nM 6.51
CHEMBL3142689 EC50 = 330.0 nM 6.48
CHEMBL328422 EC50 = 910.0 nM 6.04