Assay Detail
Functional
CHEMBL691275
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Minimum cytotoxic concentration that causes a microscopically detectable alteration of cell morphology in human embryonic lung cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.01 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92041 | — | — | 1 | 5.70 |
| CHEMBL328116 | — | — | 1 | 5.30 |
| CHEMBL88434 | — | — | 1 | 5.30 |
| CHEMBL90871 | — | — | 1 | 5.30 |
| CHEMBL88616 | — | — | 1 | 4.70 |
| CHEMBL91024 | — | — | 1 | 4.70 |
| CHEMBL419504 | — | — | 1 | 4.70 |
| CHEMBL315331 | — | — | 1 | 4.70 |
| CHEMBL327570 | — | — | 1 | 4.70 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL88271 | — | — | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92041 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL328116 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL88434 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL90871 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL88616 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL91024 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL419504 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL315331 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL327570 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL184 | ACYCLOVIR | IC50 | > | 50000.0 | nM | - |
| CHEMBL88271 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL31634 | BRIVUDINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 50000.0 | nM | - |