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Assay Detail

CHEMBL691469

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Hepatitis B virus (HBV) in 2.2.15 cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepatitis B virus
Cell Type HepG2 2.2.15
Confidence 1 — Organism
Curated By Expert

Target

Hepatitis B virus (CHEMBL613497)
Type ORGANISM
Organism Hepatitis B virus

Publication

Synthesis and antiviral activity of oxaselenolane nucleosides.
Chu CK, Ma L, Olgen S, Pierra C, Du J, Gumina G, Gullen E, Cheng YC, Schinazi RF.
J Med Chem (2000) 43 : 3906 -3912
PubMed 11052795 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 14 6.65 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL141 LAMIVUDINE 4.0 1 8.10
CHEMBL433859 1 5.92
CHEMBL127637 1 5.92
CHEMBL341515 1 -
CHEMBL339930 1 -
CHEMBL424628 1 -
CHEMBL338931 1 -
CHEMBL340754 1 -
CHEMBL125918 1 -
CHEMBL338403 1 -
CHEMBL340512 1 -
CHEMBL338804 1 -
CHEMBL421443 1 -
CHEMBL127096 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL141 LAMIVUDINE EC50 = 8.0 nM 8.10
CHEMBL433859 EC50 = 1200.0 nM 5.92
CHEMBL127637 EC50 = 1200.0 nM 5.92
CHEMBL341515 EC50 > 10000.0 nM -
CHEMBL339930 EC50 > 10000.0 nM -
CHEMBL424628 EC50 > 10000.0 nM -
CHEMBL338931 EC50 > 10000.0 nM -
CHEMBL340754 EC50 > 10000.0 nM -
CHEMBL125918 EC50 > 10000.0 nM -
CHEMBL338403 EC50 > 10000.0 nM -
CHEMBL340512 EC50 > 10000.0 nM -
CHEMBL338804 EC50 > 10000.0 nM -
CHEMBL421443 EC50 > 10000.0 nM -
CHEMBL127096 EC50 > 10000.0 nM -