Assay Detail
Functional
CHEMBL691517
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The compound was tested for antiviral activity by measuring the concentration required to reduce plaque formation against Varicella zoster TK+YS strain
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.18 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | 8.30 |
| CHEMBL92041 | — | — | 1 | 6.30 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 6.11 |
| CHEMBL90871 | — | — | 1 | 5.85 |
| CHEMBL315331 | — | — | 1 | 5.82 |
| CHEMBL91024 | — | — | 1 | 5.47 |
| CHEMBL327570 | — | — | 1 | 5.42 |
| CHEMBL88616 | — | — | 1 | - |
| CHEMBL328116 | — | — | 1 | - |
| CHEMBL88434 | — | — | 1 | - |
| CHEMBL419504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31634 | BRIVUDINE | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL92041 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL184 | ACYCLOVIR | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL90871 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL315331 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL91024 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL327570 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL88616 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL328116 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL88434 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL419504 | — | IC50 | > | 5000.0 | nM | - |