Assay Detail
Functional
CHEMBL691526
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for cytotoxic concentration required to reduce human embryonic lung cell growth by 50%
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.35 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92041 | — | — | 1 | 6.00 |
| CHEMBL328116 | — | — | 1 | 5.52 |
| CHEMBL88434 | — | — | 1 | 5.52 |
| CHEMBL90871 | — | — | 1 | 5.52 |
| CHEMBL315331 | — | — | 1 | 5.40 |
| CHEMBL91024 | — | — | 1 | 5.30 |
| CHEMBL88616 | — | — | 1 | 5.10 |
| CHEMBL327570 | — | — | 1 | 5.05 |
| CHEMBL419504 | — | — | 1 | 4.70 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | - |
| CHEMBL31634 | BRIVUDINE | 2.0 | 1 | - |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92041 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL328116 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL88434 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL90871 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL315331 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL91024 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL88616 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL327570 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL419504 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL184 | ACYCLOVIR | IC50 | > | 100000.0 | nM | - |
| CHEMBL31634 | BRIVUDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL182 | GANCICLOVIR | IC50 | > | 50000.0 | nM | - |