Assay Detail
Functional
CHEMBL691599
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Antiviral activity was measured as effective concentration required to reduce Varicella Zoster virus (YS)-induced plaque formation in human embryonic lung cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Bicyclic anti-VZV nucleosides: Thieno analogues retain full antiviral activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 7.20 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3142406 | — | — | 1 | 8.30 |
| CHEMBL144817 | — | — | 1 | 8.10 |
| CHEMBL3142473 | — | — | 1 | 8.00 |
| CHEMBL3142468 | — | — | 1 | 7.22 |
| CHEMBL3142432 | — | — | 1 | 6.85 |
| CHEMBL3142431 | — | — | 1 | 6.82 |
| CHEMBL3142474 | — | — | 1 | 6.52 |
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3142406 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL144817 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3142473 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3142468 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3142432 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3142431 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3142474 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL184 | ACYCLOVIR | EC50 | = | 1500.0 | nM | 5.82 |