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Assay Detail

CHEMBL691888

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Functional
Inhibition HCV RNA replication
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Confidence 9 — Direct single protein target
Curated By Expert

Target

RNA-directed RNA polymerase (CHEMBL4296320)
Type SINGLE PROTEIN
Organism Hepacivirus hominis

Publication

Structure-activity relationship of purine ribonucleosides for inhibition of hepatitis C virus RNA-dependent RNA polymerase.
Eldrup AB, Allerson CR, Bennett CF, Bera S, Bhat B, Bhat N, Bosserman MR, Brooks J, Burlein C, Carroll SS, Cook PD, Getty KL, MacCoss M, McMasters DR, Olsen DB, Prakash TP, Prhavc M, Song Q, Tomassini JE, Xia J.
J Med Chem (2004) 47 : 2283 -2295
PubMed 15084127 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 21 5.48 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL73809 1 6.52
CHEMBL72928 1 5.92
CHEMBL305890 1 5.16
CHEMBL73502 1 4.30
CHEMBL311635 1 -
CHEMBL1090 VIDARABINE 4.0 1 -
CHEMBL305686 CORDYCEPIN 1.0 1 -
CHEMBL73237 1 -
CHEMBL418899 2'-B-METHYL-GUANOSINE 1 -
CHEMBL309579 2'-BETA-FLUORO-2',3'-DEOXYADENOSINE 1 -
CHEMBL480143 1 -
CHEMBL307872 1 -
CHEMBL308759 1 -
CHEMBL2021379 1 -
CHEMBL75667 1 -
CHEMBL76105 1 -
CHEMBL75343 1 -
CHEMBL308370 1 -
CHEMBL2311161 1 -
CHEMBL420751 1 -
CHEMBL306299 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL73809 EC50 = 300.0 nM 6.52
CHEMBL72928 EC50 = 1200.0 nM 5.92
CHEMBL305890 EC50 = 7000.0 nM 5.16
CHEMBL73502 EC50 = 50000.0 nM 4.30
CHEMBL311635 EC50 > 50000.0 nM -
CHEMBL1090 VIDARABINE EC50 > 50000.0 nM -
CHEMBL305686 CORDYCEPIN EC50 46000.0 nM -
CHEMBL73237 EC50 > 50000.0 nM -
CHEMBL418899 2'-B-METHYL-GUANOSINE EC50 3500.0 nM -
CHEMBL309579 2'-BETA-FLUORO-2',3'-DEOXYADENOSINE EC50 > 50000.0 nM -
CHEMBL480143 EC50 > 50000.0 nM -
CHEMBL307872 EC50 > 50000.0 nM -
CHEMBL308759 EC50 > 50000.0 nM -
CHEMBL2021379 EC50 > 50000.0 nM -
CHEMBL75667 EC50 > 50000.0 nM -
CHEMBL76105 EC50 > 50000.0 nM -
CHEMBL75343 EC50 > 50000.0 nM -
CHEMBL308370 EC50 > 50000.0 nM -
CHEMBL2311161 EC50 > 50000.0 nM -
CHEMBL420751 EC50 > 50000.0 nM -
CHEMBL306299 EC50 > 50000.0 nM -