Assay Detail
Functional
CHEMBL692308
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Cytotoxicity against HCT116 cells.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Topoisomerase II-mediated DNA cleavage by adocia- and xestoquinones from the Philippine sponge Xestospongia sp.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 4.77 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.60 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 5.20 |
| CHEMBL476648 | ADOCIAQUINONE B | — | 1 | 4.68 |
| CHEMBL336253 | ADOCIAQUINONE A | — | 1 | 4.62 |
| CHEMBL341831 | — | — | 1 | 4.55 |
| CHEMBL344243 | — | — | 1 | 4.55 |
| CHEMBL138236 | — | — | 1 | 4.48 |
| CHEMBL138922 | — | — | 1 | 4.48 |
| CHEMBL344218 | — | — | 1 | - |
| CHEMBL140718 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL43 | AMSACRINE | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL476648 | ADOCIAQUINONE B | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL336253 | ADOCIAQUINONE A | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL341831 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL344243 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL138236 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL138922 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL344218 | — | IC50 | = | 143000.0 | nM | - |
| CHEMBL140718 | — | IC50 | = | 148000.0 | nM | - |