Assay Detail
Functional
CHEMBL692313
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of proliferation of human colon cancer line 116 after 72 hrs incubation.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Taxol structure-activity relationships: synthesis and biological evaluation of taxol analogs modified at C-7
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.27 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL303470 | — | — | 1 | 8.80 |
| CHEMBL304291 | — | — | 1 | 8.70 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.52 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.40 |
| CHEMBL308440 | — | — | 1 | 8.40 |
| CHEMBL70257 | — | — | 1 | 8.33 |
| CHEMBL304081 | — | — | 1 | 8.30 |
| CHEMBL72846 | — | — | 1 | 8.22 |
| CHEMBL70320 | — | — | 1 | 8.15 |
| CHEMBL432137 | — | — | 1 | 8.10 |
| CHEMBL428623 | — | — | 1 | 7.96 |
| CHEMBL428278 | — | — | 1 | 7.34 |
| CHEMBL262233 | — | — | 1 | - |
| CHEMBL386608 | — | — | 1 | - |
| CHEMBL262994 | — | — | 1 | - |
| CHEMBL430801 | — | — | 1 | - |
| CHEMBL408559 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL303470 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL304291 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL308440 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL70257 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL304081 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL72846 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL70320 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL432137 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL428623 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL428278 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL262233 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL386608 | — | IC50 | > | 3900.0 | nM | - |
| CHEMBL262994 | — | IC50 | > | 78.0 | nM | - |
| CHEMBL430801 | — | IC50 | > | 60.0 | nM | - |
| CHEMBL408559 | — | IC50 | > | 78.0 | nM | - |