Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL304291

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC(=O)O[C@H]1C(=O)[C@@]2(C)C([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@H]2O

Basic Information

ChEMBL ID CHEMBL304291
Phase Preclinical
Structure Type MOL
InChI Key RCINICONZNJXQF-WLUSQHPBSA-N
2
Targets
5
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

853.9
MW (Da)
3.74
ALogP
14
HBA
4
HBD
221.3
PSA (Ų)
0.13
QED
2
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C47H51NO14
MW 853.92
Aromatic Rings 3
Heavy Atoms 62
NP-Likeness 1.87

Activity Summary

EC50 3 meas. best 6.65
IC50 2 meas. best 8.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
HCT-116
CHEMBL394
IC50 8.7 8.7 2.0 1
Unchecked
CHEMBL612545
IC50 7.14 7.14 71.9 1
Unchecked
CHEMBL612545
EC50 6.65 6.59 222.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80075-X Mus musculus 2
- 10.1016/S0960-894X(00)80075-X Tubulin alpha chain 1
- 10.1016/S0960-894X(00)80075-X HCT-116 1

Data from ChEMBL 36 via Core Engine