Assay Detail

CHEMBL692341

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Functional

pA2 was measured as Calcium antagonistic activity 30 min after administration

ChEMBL ↗

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Target

Cavia porcellus (CHEMBL369) ↗

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Primary target Cavia porcellus

CHEMBL369

Anchored from Assay target.

Protein identity Cavia porcellus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Cavia porcellus
Confidence	1 — Organism
Curated By	Intermediate

Target

Cavia porcellus (CHEMBL369) ↗

Type	ORGANISM
Organism	Cavia porcellus

Publication

Organic phosphorus compounds. 1. 4-(Benzothiazol-2-yl)benzylphosphonate as potent calcium antagonistic vasodilator.

Yoshino K, Kohno T, Uno T, Morita T, Tsukamoto G.
J Med Chem (1986) 29 : 820 -825
PubMed 3701791 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Kd	2	6.65	6.92

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL39516	FOSTEDIL	2.0	1	6.92
CHEMBL1697	DILTIAZEM HYDROCHLORIDE	4.0	1	6.38

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL39516	FOSTEDIL	Kd	=	120.23	nM	6.92
CHEMBL1697	DILTIAZEM HYDROCHLORIDE	Kd	=	416.87	nM	6.38