Assay Detail
Binding
CHEMBL692702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound tested for its inhibitory activity against Histamine H1 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 10.00 | 10.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 10.70 |
| CHEMBL445 | NORTRIPTYLINE | 4.0 | 1 | 10.30 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | 10.22 |
| CHEMBL415 | CLOMIPRAMINE | 4.0 | 1 | 9.70 |
| CHEMBL72 | DESIPRAMINE | 4.0 | 1 | 9.10 |
| CHEMBL1628227 | DOXEPIN | 4.0 | 1 | - |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 0.02 | nM | 10.70 |
| CHEMBL445 | NORTRIPTYLINE | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL11 | IMIPRAMINE | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL415 | CLOMIPRAMINE | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL72 | DESIPRAMINE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1628227 | DOXEPIN | IC50 | = | 0.003 | nM | - |
| CHEMBL6437 | MIANSERIN | IC50 | = | 0.006 | nM | - |