Assay Detail
Binding
CHEMBL692703
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards histamine H1 receptor from rat brain membranes using [3H]mepyramine as radioligand
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: chemistry and pharmacological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.81 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.64 |
| CHEMBL72292 | — | — | 1 | 7.33 |
| CHEMBL430798 | — | — | 1 | 6.92 |
| CHEMBL310712 | — | — | 1 | 6.14 |
| CHEMBL831 | LOXAPINE | 4.0 | 1 | 6.00 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL72292 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL430798 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL310712 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL831 | LOXAPINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL54 | HALOPERIDOL | IC50 | > | 1000.0 | nM | - |