Assay Detail
Binding
CHEMBL692705
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Inhibitory binding of [3H]mepyramine to histamine H1 receptors in rat brain membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of triflate-substituted analogues of clozapine: identification of a novel atypical neuroleptic.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.04 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.64 |
| CHEMBL72292 | — | — | 1 | 7.33 |
| CHEMBL310712 | — | — | 1 | 6.14 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL72292 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL310712 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL54 | HALOPERIDOL | IC50 | > | 1000.0 | nM | - |