Assay Detail
Functional
CHEMBL692773
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Effective concentration required to inhibit Tyrosine kinase deficient (TK-) Varicella-Zoster virus-induced cytopathicity by 50% in 07/01 strain HEL cell lines
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 4.23 | 4.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | 4.0 | 1 | 4.39 |
| CHEMBL606446 | — | — | 1 | 4.06 |
| CHEMBL140440 | — | — | 1 | - |
| CHEMBL607985 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL184 | ACYCLOVIR | EC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL606446 | — | EC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL140440 | — | EC50 | = | 154000.0 | nM | - |
| CHEMBL607985 | — | EC50 | = | 200000.0 | nM | - |