Assay Detail
Functional
CHEMBL693096
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant [100(nM)] in myenteric plexus-longitudinal muscle of guinea pig small intestine using the cannabinoid receptor agonist.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Small intestine |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 9.06 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285932 | — | — | 1 | 9.66 |
| CHEMBL111 | RIMONABANT | 4.0 | 1 | 9.60 |
| CHEMBL286188 | — | — | 1 | 9.49 |
| CHEMBL349955 | — | — | 1 | 8.58 |
| CHEMBL424527 | — | — | 1 | 7.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285932 | — | Kd | = | 0.22 | nM | 9.66 |
| CHEMBL111 | RIMONABANT | Kd | = | 0.25 | nM | 9.60 |
| CHEMBL286188 | — | Kd | = | 0.32 | nM | 9.49 |
| CHEMBL349955 | — | Kd | = | 2.63 | nM | 8.58 |
| CHEMBL424527 | — | Kd | = | 11.2 | nM | 7.95 |