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Assay Detail

CHEMBL693410

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against human rhinovirus-14 in HeLa cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus sp.
Cell Type HeLa
Confidence 1 — Organism
Curated By Expert

Target

Human rhinovirus sp. (CHEMBL612470)
Type ORGANISM
Organism Human rhinovirus sp.

Publication

Small peptidic aldehyde inhibitors of human rhinovirus 3C protease
Shepherd TA, Cox GA, McKinney E, Tang J, Wakulchik M, Zimmerman RE, Villarreal EC
Bioorg Med Chem Lett (1996) 6 : 2893 -2896
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.66 6.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3142717 1 6.47
CHEMBL329083 1 5.47
CHEMBL318261 1 5.01
CHEMBL92708 CALPEPTIN 1 4.75
CHEMBL98827 1 4.69
CHEMBL318779 1 4.62
CHEMBL421000 1 4.41
CHEMBL97671 1 4.38
CHEMBL99195 1 4.33
CHEMBL317800 1 4.15
CHEMBL319062 1 4.09
CHEMBL95363 1 4.09
CHEMBL319063 1 4.08
CHEMBL191881 LEUPEPTIN 1 -
CHEMBL330400 1 -
CHEMBL59769 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3142717 IC50 = 340.0 nM 6.47
CHEMBL329083 IC50 = 3400.0 nM 5.47
CHEMBL318261 IC50 = 9700.0 nM 5.01
CHEMBL92708 CALPEPTIN IC50 = 17700.0 nM 4.75
CHEMBL98827 IC50 = 20300.0 nM 4.69
CHEMBL318779 IC50 = 23700.0 nM 4.62
CHEMBL421000 IC50 = 39300.0 nM 4.41
CHEMBL97671 IC50 = 42000.0 nM 4.38
CHEMBL99195 IC50 = 46800.0 nM 4.33
CHEMBL317800 IC50 = 71300.0 nM 4.15
CHEMBL319062 IC50 = 81200.0 nM 4.09
CHEMBL95363 IC50 = 81900.0 nM 4.09
CHEMBL319063 IC50 = 84100.0 nM 4.08
CHEMBL191881 LEUPEPTIN IC50 > 224000.0 nM -
CHEMBL330400 IC50 > 224000.0 nM -
CHEMBL59769 IC50 = 400000.0 nM -