Assay Detail
Functional
CHEMBL693735
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration of the Compound was tested against LTD4 induced contraction of guinea pig trachea.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Analogues of natural phloroglucinols as antagonists against both thromboxane A2 and leukotriene D4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.81 | 6.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19819 | — | — | 1 | 6.46 |
| CHEMBL15862 | — | — | 1 | 6.35 |
| CHEMBL277845 | — | — | 1 | 6.25 |
| CHEMBL19916 | — | — | 1 | 6.24 |
| CHEMBL6931 | — | — | 1 | 5.92 |
| CHEMBL20021 | — | — | 1 | 5.92 |
| CHEMBL19959 | — | — | 1 | 5.85 |
| CHEMBL20627 | — | — | 1 | 5.85 |
| CHEMBL20050 | — | — | 1 | 5.64 |
| CHEMBL20022 | — | — | 1 | 5.23 |
| CHEMBL281335 | — | — | 1 | 5.12 |
| CHEMBL19655 | — | — | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19819 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL15862 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL277845 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL19916 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL6931 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL20021 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL19959 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL20627 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL20050 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL20022 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL281335 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL19655 | — | IC50 | = | 12000.0 | nM | 4.92 |