Assay Detail
Binding
CHEMBL694442
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]-pyrilamine from H1 receptor in rat brain membrane.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Dual antagonists of platelet activating factor and histamine. 2. pyridine ring substitution of N-acetyl-4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)piperidines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.65 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL11001 | — | — | 1 | 8.00 |
| CHEMBL268695 | — | — | 1 | 7.70 |
| CHEMBL11313 | — | — | 1 | 7.40 |
| CHEMBL275109 | — | — | 1 | 7.16 |
| CHEMBL11159 | — | — | 1 | 7.00 |
| CHEMBL11158 | — | — | 1 | 6.68 |
| CHEMBL10826 | — | — | 1 | 6.64 |
| CHEMBL274357 | — | — | 1 | 6.64 |
| CHEMBL10981 | — | — | 1 | 6.62 |
| CHEMBL10971 | SCH-37370 | — | 1 | 6.50 |
| CHEMBL11136 | — | — | 1 | 6.37 |
| CHEMBL268022 | — | — | 1 | 6.16 |
| CHEMBL10855 | — | — | 1 | 5.99 |
| CHEMBL11435 | — | — | 1 | 5.94 |
| CHEMBL269460 | — | — | 1 | 5.87 |
| CHEMBL275993 | — | — | 1 | 5.80 |
| CHEMBL10903 | — | — | 1 | - |
| CHEMBL274153 | — | — | 1 | - |
| CHEMBL11222 | — | — | 1 | - |
| CHEMBL11055 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL11001 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL268695 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL11313 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL275109 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL11159 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL11158 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL10826 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL274357 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL10981 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL10971 | SCH-37370 | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL11136 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL268022 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL10855 | — | Ki | = | 1030.0 | nM | 5.99 |
| CHEMBL11435 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL269460 | — | Ki | = | 1360.0 | nM | 5.87 |
| CHEMBL275993 | — | Ki | = | 1580.0 | nM | 5.80 |
| CHEMBL10903 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL274153 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL11222 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL11055 | — | Ki | > | 10000.0 | nM | - |