Assay Detail
Functional
CHEMBL694535
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for inhibition of electrically evoked contractions of the myenteric plexus-longitudinal muscle of the Guinea pig small intestine
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Muscle tissue |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: insights gained from (E)- and (Z)-naphthylidene indenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.58 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | — | 1 | 8.31 |
| CHEMBL127644 | — | — | 1 | 8.18 |
| CHEMBL123916 | — | — | 1 | 7.28 |
| CHEMBL148805 | — | — | 1 | 6.55 |
| CHEMBL149599 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188 | WIN-552122 | EC50 | = | 4.92 | nM | 8.31 |
| CHEMBL127644 | — | EC50 | = | 6.57 | nM | 8.18 |
| CHEMBL123916 | — | EC50 | = | 52.86 | nM | 7.28 |
| CHEMBL148805 | — | EC50 | = | 283.13 | nM | 6.55 |
| CHEMBL149599 | — | EC50 | > | 3162.0 | nM | - |