Assay Detail
Functional
CHEMBL694633
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Cytosolic phospholipase A2 (c-PLA2) inhibitory potency of the compound was evaluated by measuring the calcium ionophore A-23,187-induced arachidonic acid release from human platelets
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A(2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.71 | 6.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL87987 | — | — | 1 | 6.07 |
| CHEMBL87707 | — | — | 1 | 5.60 |
| CHEMBL313460 | — | — | 1 | 5.60 |
| CHEMBL312824 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL87987 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL87707 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL313460 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL312824 | — | IC50 | = | 2600.0 | nM | 5.58 |