Assay Detail
Binding
CHEMBL694794
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Inhibitory activity against IkappaB kinase(IKK) isolated from HeLa cells activated with recombinant MEEK1 in an ELISA phosphorylation assay.
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHEMBL3476) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel IKK inhibitors: beta-carbolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.97 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81603 | — | — | 1 | 7.10 |
| CHEMBL79004 | — | — | 1 | 7.00 |
| CHEMBL81229 | — | — | 1 | 6.85 |
| CHEMBL312651 | — | — | 1 | 6.77 |
| CHEMBL78464 | — | — | 1 | 6.70 |
| CHEMBL80843 | — | — | 1 | 6.52 |
| CHEMBL81169 | — | — | 1 | 6.22 |
| CHEMBL311201 | — | — | 1 | 6.22 |
| CHEMBL80121 | — | — | 1 | 6.22 |
| CHEMBL310179 | — | — | 1 | 6.22 |
| CHEMBL312698 | — | — | 1 | 6.16 |
| CHEMBL78862 | — | — | 1 | 6.16 |
| CHEMBL310975 | — | — | 1 | 6.00 |
| CHEMBL78917 | — | — | 1 | 6.00 |
| CHEMBL81214 | — | — | 1 | 5.96 |
| CHEMBL78618 | — | — | 1 | 5.96 |
| CHEMBL78885 | — | — | 1 | 5.89 |
| CHEMBL81781 | — | — | 1 | 5.89 |
| CHEMBL78879 | — | — | 1 | 5.75 |
| CHEMBL312320 | — | — | 1 | 5.75 |
| CHEMBL81170 | — | — | 1 | 5.70 |
| CHEMBL312170 | — | — | 1 | 5.52 |
| CHEMBL82136 | — | — | 1 | 5.52 |
| CHEMBL81809 | — | — | 1 | 5.50 |
| CHEMBL81838 | — | — | 1 | 5.40 |
| CHEMBL80619 | — | — | 1 | 5.40 |
| CHEMBL312676 | — | — | 1 | 5.08 |
| CHEMBL309953 | — | — | 1 | 4.96 |
| CHEMBL275224 | NORHARMANE | — | 1 | 4.82 |
| CHEMBL309265 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81603 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL79004 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL81229 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL312651 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL78464 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL80843 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL81169 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL311201 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL80121 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL310179 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL312698 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL78862 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL310975 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL78917 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL78618 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL81214 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL81781 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL78885 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL78879 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL312320 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL81170 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL312170 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL82136 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL81809 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL81838 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL80619 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL312676 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL309953 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL275224 | NORHARMANE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL309265 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL311306 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL82137 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL81315 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL312648 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL80793 | — | IC50 | > | 20000.0 | nM | - |