Assay Detail
Binding
CHEMBL695165
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Inhibition of [3H]pyrilamine binding to Histamine H1 receptor in rat cortex
5
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New benzocycloalkylpiperazines, potent and selective 5-HT1A receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.23 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL354210 | — | — | 2 | 7.52 |
| CHEMBL366388 | — | — | 1 | 7.38 |
| CHEMBL368061 | — | — | 2 | 7.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL354210 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL366388 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL368061 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL354210 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL368061 | — | Ki | = | 140.0 | nM | 6.85 |