Assay Detail
Binding
CHEMBL695907
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Inhibition of human recombinant hormone sensitive lipase (HSL)
87
Total Activities
87
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 87 | 7.65 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL419197 | — | — | 1 | 9.00 |
| CHEMBL322794 | — | — | 1 | 9.00 |
| CHEMBL107197 | — | — | 1 | 8.70 |
| CHEMBL109116 | — | — | 1 | 8.70 |
| CHEMBL320813 | — | — | 1 | 8.52 |
| CHEMBL106581 | — | — | 1 | 8.52 |
| CHEMBL106126 | — | — | 1 | 8.52 |
| CHEMBL106756 | — | — | 1 | 8.40 |
| CHEMBL110343 | — | — | 1 | 8.40 |
| CHEMBL110763 | — | — | 1 | 8.40 |
| CHEMBL105834 | — | — | 1 | 8.40 |
| CHEMBL106045 | — | — | 1 | 8.30 |
| CHEMBL110653 | — | — | 1 | 8.30 |
| CHEMBL107365 | — | — | 1 | 8.30 |
| CHEMBL106314 | — | — | 1 | 8.30 |
| CHEMBL321903 | — | — | 1 | 8.22 |
| CHEMBL110655 | — | — | 1 | 8.22 |
| CHEMBL316549 | — | — | 1 | 8.22 |
| CHEMBL108519 | — | — | 1 | 8.22 |
| CHEMBL106200 | — | — | 1 | 8.22 |
| CHEMBL108325 | — | — | 1 | 8.22 |
| CHEMBL110716 | — | — | 1 | 8.22 |
| CHEMBL108207 | — | — | 1 | 8.15 |
| CHEMBL321483 | — | — | 1 | 8.15 |
| CHEMBL110597 | — | — | 1 | 8.15 |
| CHEMBL324436 | — | — | 1 | 8.10 |
| CHEMBL322051 | — | — | 1 | 8.05 |
| CHEMBL109182 | — | — | 1 | 8.00 |
| CHEMBL106784 | — | — | 1 | 8.00 |
| CHEMBL323458 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL419197 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL322794 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL109116 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL107197 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL320813 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL106581 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL106126 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL105834 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL110763 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL106756 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL110343 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL106314 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL107365 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL110653 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL106045 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL321903 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL110716 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL108325 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL106200 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL108519 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL316549 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL110655 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL108207 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL321483 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL110597 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL324436 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL322051 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL109182 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL106784 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL323458 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL323419 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL320249 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL108523 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL106504 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL322780 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL110322 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL107712 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL320525 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL107235 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL323173 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL105774 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL106375 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108270 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL317407 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL320708 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL106987 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL317643 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL321433 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL108326 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL106319 | — | IC50 | = | 37.0 | nM | 7.43 |