Compound Detail
CHEMBL106784
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Basic Information
| ChEMBL ID | CHEMBL106784 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RXLKHXHQPCQNHH-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
342.4
MW (Da)
3.80
ALogP
4
HBA
0
HBD
55.5
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hormone-sensitive lipase CHEMBL3590 | IC50 | 8.4 | 8.2 | 4.0 | 2 |
| Hormone-sensitive lipase CHEMBL5582 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hormone-sensitive lipase | IC50 | = | 4.0 | nM | 8.4 | Inhibition of forskolin-stimulated lipolysis in differentiated 3T3-L1 cells | 15149665 |
| Hormone-sensitive lipase | IC50 | = | 10.0 | nM | 8.0 | Inhibition of human recombinant hormone sensitive lipase (HSL) | 15149665 |
| Hormone-sensitive lipase | IC50 | = | 10.0 | nM | 8.0 | Inhibition of HSL in Wistar rat isolated fat cells by spectrophotometric assay | 18808096 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15149665 | 10.1016/j.bmcl.2004.04.015 | Hormone-sensitive lipase | 2 |
| 18808096 | 10.1021/jm800718k | Hormone-sensitive lipase | 1 |
Data from ChEMBL 36 via Core Engine