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Assay Detail

CHEMBL696031

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HCMV was determined by plaque reduction assay using HFF cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HFF
Confidence 1 — Organism
Curated By Expert

Target

HFF (CHEMBL614071)
Type CELL-LINE
Organism Homo sapiens

Publication

6-N-Acyltriciribine analogues: structure-activity relationship between acyl carbon chain length and activity against HIV-1.
Porcari AR, Ptak RG, Borysko KZ, Breitenbach JM, Drach JC, Townsend LB.
J Med Chem (2000) 43 : 2457 -2463
PubMed 10882373 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.20 6.35

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL608301 1 6.35
CHEMBL462018 TRICIRIBINE PHOSPHATE 2.0 1 6.10
CHEMBL331237 TRICIRIBINE 1 5.60
CHEMBL611245 1 5.06
CHEMBL611242 1 5.00
CHEMBL608901 1 4.96
CHEMBL611850 1 4.92
CHEMBL607724 1 4.92
CHEMBL607723 1 4.92
CHEMBL611243 1 4.92
CHEMBL609191 1 4.40
CHEMBL610657 1 -
CHEMBL608900 1 -
CHEMBL610370 1 -
CHEMBL610949 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL608301 IC50 = 450.0 nM 6.35
CHEMBL462018 TRICIRIBINE PHOSPHATE IC50 = 800.0 nM 6.10
CHEMBL331237 TRICIRIBINE IC50 = 2500.0 nM 5.60
CHEMBL611245 IC50 = 8800.0 nM 5.06
CHEMBL611242 IC50 = 10000.0 nM 5.00
CHEMBL608901 IC50 = 11000.0 nM 4.96
CHEMBL611850 IC50 = 12000.0 nM 4.92
CHEMBL607724 IC50 = 12000.0 nM 4.92
CHEMBL607723 IC50 = 12000.0 nM 4.92
CHEMBL611243 IC50 = 12000.0 nM 4.92
CHEMBL609191 IC50 = 40000.0 nM 4.40
CHEMBL610657 IC50 > 100000.0 nM -
CHEMBL608900 IC50 > 100000.0 nM -
CHEMBL610370 IC50 > 100000.0 nM -
CHEMBL610949 IC50 > 100000.0 nM -